The Effect of a Period of Resistance Training on BDNF Gene Depletion and Poor Memory of Rats Poisoned with Anabolic Steroid Stanazolol

Introduction: Nowadays, the use of energy substances has become a complex problem in sports, in which the role of anabolic-androgenic asteroids is undeniable. The aim of this study was to evaluate the effect of a period of resistance training on BDNF gene expression and poor memory in rats poisoned with anabolic steroid stanazolol. Methods: In this experimental study, 18 Sprague-Dovali rats with a weight range of 150 to 200 g and an average age of 8 weeks were randomly divided into three groups of 6 series including 1) sham (normal saline intake), 2) stanazole, 3) Stanazol was administered with resistance training. For eight weeks, the stanazol and resistance training + stanazole groups received 5 mg / kg of stanazole peritoneally daily, and the resistance training + stanazol group performed three sessions per week of resistance training. BDNF was measured in hippocampal tissue by ELISA and retention memory using shuttle box test. Kolmogorov-Smirnov test was used to evaluate the normality of the distribution of findings and one-way analysis of variance with Tukey post hoc test in SPSS software was used to analyze the results (P≥0.05). Results: Stanazolol had a significant effect on reducing BDNF gene expression and nausea memory (P ≤ 0.001). However, resistance training increased BDNF (P ≤ 0.001) and nausea memory (P ≤ 0.006) in mice. Field poisoned with stanazolol. Conclusions: According to the results of the present study, it seems that resistance training has synergistic effects on improving BDNF and laziness in rats poisoned with stanazol.